Annona muricata fruits are traditionally used for the treatment of diabetes mellitus. Now a days everted rat gut sac technique was used to investigate the D-glucose uptake activity. In current study, modified everted gut sac technique was performed with chick ileum instead of rat ileum. In this study the effect of ethanolic extract of Annona muricata peel on glucose uptake by everted guts was studied. The guts were mounted in a gut sac bath and different concentrations of glucose were added into mucosal fluid. Just before starting the experiment, the ethanolic extract of Annona muricata peel was also added in the same compartment. After one hour of incubation, the glucose concentration in mucosal fluid and serosal fluid was measured by using glucometer.
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